Effects of adolescent THC exposure on the behavioral effects of cocaine in adult Sprague-Dawley rats
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Adolescent Female Cannabinoid Exposure Diminishes the Reward-Facilitating Effects of Δ9-Tetrahydrocannabinol and d-Amphetamine in the Adult Male Offspring
Marijuana is currently the most commonly abused illicit drug. According to recent studies, cannabinoid use occurring prior to pregnancy can impact brain plasticity and behavior in future generations. The purpose of the present study was to determine whether adolescent exposure of female rats to Δ9-tetrahydrocannabinol (Δ9-THC) induces transgenerational effects on the reward-facilitating effects...
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BACKGROUND Feeding conditions can influence dopamine neurotransmission and impact behavioral and neurochemical effects of drugs acting on dopamine systems. This study examined whether eating high fat chow alters the locomotor effects of cocaine and dopamine transporter activity in adolescent (postnatal day 25) and adult (postnatal day 75) male Sprague-Dawley rats. METHODS Dose-response curves...
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Background: One of the most growing diseases is the onset of atherosclerosis which can be started from a fetal age. As a result, the intrauterine environment plays a role at risk of spreading this disease. Changes in vascular function considered to be as an indicator for vascular disease. Effective factors on vascular function are enzyme eNOS and apoptotic regulator factors included BCL-2 an...
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Human drug experimentation begins during late childhood and early adolescence, a critical time in physical and CNS development, when the immature CNS is vulnerable to the long-term effects of psychoactive drugs. Few preclinical animal studies have investigated responses to such drugs in a developmental stage equivalent to late childhood of humans. We used a rodent model to examine behavioral re...
متن کاملDifferential Behavioral and Neurobiological Effects of Chronic Corticosterone Treatment in Adolescent and Adult Rats
Adolescence is a critical period with ongoing maturational processes in stress-sensitive systems. While adolescent individuals show heightened stress-induced hormonal responses compared to adults, it is unclear whether and how the behavioral and neurobiological consequences of chronic stress would differ between the two age groups. Here we address this issue by examining the effects of chronic ...
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تاریخ انتشار 2014